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KMID : 0191119990140060648
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Journal of Korean Medical Science
1999 Volume.14 No. 6 p.648 ~ p.652
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Effects of BCG, lymphotoxin and bee venom on insulitis and development of IDDM in non-obese diabetic mice
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Kim JY
Cho SH/Kim YW/Jang EC/Park SY/Kim EJ/Lee SK
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Abstract
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To investigate whether BCG, lymphtoxin (LT) or bee venom (BV) can prevent insulitis and development of
diabetes in non-obese diabetic (NOD) mice, we measured the degree of insulitis and incidence of diabetes
in 24 ICR and 96 female NOD mice. NOD mice were randomly assigned to control, BCG-, LT-, and BV-treated
groups. The BCG was given once at 6 weeks of age, and LT was given in 3 weekly doses from the age of 4 to
10 weeks. The BV was injected in 2 weekly doses from the age of 4 to 10 weeks. Diabetes started in control
group at 18 weeks of age, in BCG group at 24 weeks of age, and in LT- or BV-treated group at 23 weeks of
age. Cumulative incidences of diabetes at 25 weeks of age in control, BCG-, LT-, and BV-treated NOD mice
are 58, 17, 25, and 21%, respectively. Incidence and severity of insulitis were reduced by BCG, LT and BV
treatment. In conclusion, these results suggest that BCG, LT or BV treatment in NOD mice at early age
inhibit insulitis, onset and cumulative incidence of diabetes.
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KEYWORD
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